AAA ATPase p97/VCP interacts with gp78: a ubiquitin ligase for ER-associated degradation Running title: p97/VCP and gp78 interaction in ERAD
نویسندگان
چکیده
Abbreviations used are: AAA ATPase: ATPase associated with various cellular activities; VCP: valosin-containing protein; ER: endoplasmic reticulum; ERAD: ERassociated degradation; NZF: Npl4 zinc finger; UBA domain: Ubiquitin-associated domain; GST: glutathione S-transferase; HA: hemagglutinin; IB: immunoblotting; IP: immunoprecipitation; RNAi: RNA interference; siRNA: small interference RNA; RING: really interesting new gene; GFP: green fluorescent protein JBC Papers in Press. Published on September 1, 2004 as Manuscript M409034200
منابع مشابه
Regulation of ER-associated degradation via p97/VCP-interacting motif.
p97/VCP (valosin-containing protein) is a cytosolic AAA (ATPase associated with various cellular activities) essential for retrotranslocation of misfolded proteins during ERAD [ER (endoplasmic reticulum)-associated degradation]. gp78, an ERAD ubiquitin ligase, is one of the p97/VCP recruitment proteins localized to the ER membrane. A newly identified VIM (p97/VCP-interacting motif) in gp78 has ...
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